Rheumatoid Arthritis Cure: Is There Such A Thing?

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Do u know why there is association between thalassemia minor and seronegative arthritis?

Simply put, seronegative arthritis is arthritis negative for the presence of rheumatoid factor (-RF). People with rheumatoid arthritis (RA) often have this factor, BUT not always. In other words, one can have RA without having rheumatoid factor. If people have RA with positive RF, then they have seropositive arthritis.

Seronegative arthritis covers ankylosing spondylitis, Reiter’s, Psoriatic arthritis (AS, ReA, PsA) for example. Both types, however, do share an autoimmune component.

I found this blurb from 1999 as well (link below):
“Unlike the description of the “classic triad,” arthralgia is the most common symptom of hemochromatosis. However, nothing is distinctive about this symptom. Arthritis is common and often misdiagnosed as seronegative rheumatoid arthritis. A pattern of arthritis involving the metacarpophalangeal and proximal interphalangeal joints of the second and third fingers suggests hemochromatosis”

From Wikipedia:
“Thalassemia (British spelling, “thalassaemia”) is an inherited autosomal recessive blood disease. In thalassemia, the genetic defect results in reduced rate of synthesis of one of the globin chains that make up hemoglobin. Reduced synthesis of one of the globin chains causes the formation of abnormal hemoglobin molecules, and this in turn causes the anemia which is the characteristic presenting symptom of the thalassemias.”

Thalassemia minor is one of the thalassemias. I’ll put the link up so you can read the entire article yourself.

Here’s a brief summary, but you should read the articles below.
Thalassemia minor seems to indicate that you carry one of the thalassemia genes. Major indicates you carry both and are affected. People with a thalassemia have a defect in one of the globin chains. This is in turn often leads to anemia—abnormally shaped red blood cells, etc. Anemia can be treated with blood transfusions, BUT that can in turn lead to iron overload which can negatively affect all the major organs in your body. This is called hemachromatosis.

Hemachromatosis can manifest as symptoms of seronegative arthritis.

I hope this makes sense. If you google “thalassemia minor” “seronegative arthritis” and -”yahoo answers” (minus yahoo answers) to get rid of your question from the search, quite a few med journal articles come up that you can read.

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