Rheumatoid Arthritis Genetic Factors
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What are the chances of being the first to have rheumatoid arthritis?
Nobody in my family history on either side has already diagnosed with rheumatoid arthritis. From what I understand this disease has a genetic component. An ER doc told me that I tested positive for rheumatoid factor and probably had rheumatoid arthritis. I need to go to another doctor but I have not yet. But I will soon. What I wonder now, is it a study to see how many times people develop this condition, no family history? Do you know if this is common or rare? I have pain in joints and cracks in my feet and deformed joints in my hands. I also had an infected lymph node and after a day or two so that my feet were very inflamed and swollen and I could barely walk. my hands started too badly. is when I went to emergency and they checked me for rheumatoid factor. oh yeah I am 20 years old btw. and I had some of these symptoms since my early adolescence or even during my childhood.
Not unprecedented. RA is an autoimmune disease. There is a huge component to the hereditary autoimmune disease, but other factors seem influence the disease appears or not in a single individual. Sometimes the tendency autoimmune cause different diseases in different family members. A report can have multiple sclerosis, lupus distant cousin, and a great-great maternal Graves disease or myasthenia gravis. You can Be the first person in the family to have autoimmune disease, because genetic mutations do not start with individuals. It is also possible to be the first person in the family * * known to be diagnosed with an autoimmune disease, since many of them require both a predisposition genetics and a kind of relaxation, such as high levels of estrogen, a viral infection, or gender. Someone who is not exposed to these triggers may act as silent carriers. You may have to come back four generations or more to find a relative affected and if you go back that far, it is possible your ancestors died young before they develop the disease or were so poor that they have not get a diagnosis. Edit to avoid a misunderstanding: rheumatoid arthritis is not caused by high fever in childhood. It is "Rheumatic fever, a disease completely and totally independent. The name is the only similarity between the two conditions.
Genome-Wide Association Studies for the Rest of Us: Final Panel Discussion